Nonspecific esterase activity expressed in Weibel-Palade bodies of cloned guinea pig aortic endothelial cells.
نویسندگان
چکیده
منابع مشابه
Dynamics and plasticity of Weibel-Palade bodies in endothelial cells.
Agonist-induced release of endothelial cell specific storage granules, designated Weibel-Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to changes in its micro-environment. Originally being defined as an intracellular storage pool for von Willebrand factor (VWF), it has recently been shown that an increasing number of other components, including P-selectin, i...
متن کاملMultigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells.
Regulated exocytosis of Weibel-Palade bodies (WPBs) is a pivotal mechanism via which vascular endothelial cells initiate repair in response to injury and inflammation. Several pathways have been proposed to enable differential release of bioactive molecules from WPBs under different pathophysiologic conditions. Due to the complexity, many aspects of WPB biogenesis and exocytosis are still poorl...
متن کاملWeibel-Palade bodies in Kaposi's sarcoma cells.
Russell Jones et al recently reported immunohistochemical findings which favour the hypothesis that Kaposi's sarcoma cells are derived from lymphatic endothelium.' They stated that "ultrastructural observations of AIDS (acquired immune deficiency syndrome) and non-AIDS related Kaposi's sarcoma have failed to identify Weibel-Palade bodies commonly regarded as a marker for vascular endothelium." ...
متن کاملRab35 protein regulates evoked exocytosis of endothelial Weibel–Palade bodies
Weibel-Palade bodies (WPB) are secretory organelles of endothelial cells that undergo evoked exocytosis following intracellular Ca2+ or cAMP elevation, thereby supplying the vasculature with factors controlling hemostasis. Several cytosolic and membrane-associated proteins, including the Rab family members Rab3, Rab15, and Rab27a, have been implicated in regulating the acute exocytosis of WPB. ...
متن کاملImmunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells
Immunofluorescence staining of cultured human umbilical vein endothelial cells has shown the presence of von Willebrand protein in the perinuclear region, in small rodlike structures through the cytoplasm, and on filaments of the extracellular matrix. Nonendothelial cells showed no staining with anti-von Willebrand protein antiserum. At the light microscope level, immunoperoxidase treatment of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 1987
ISSN: 0022-1554,1551-5044
DOI: 10.1177/35.5.3559181